Tag-arkiv: major depression

SSRI kan nedsætte antallet af selvmord hos voksne


Selektive serotonin reuptake hæmmere (SSRI) kan mindske risikoen for selvmord hos deprimeret voksne, ifølge en undersøgelse foretaget af forskere fra Verdenssundhedsorganisationen (WHO) og universitetet i Verona, Italien,  offentliggjort i seneste nummer af Canadian Medical Association Journal (CMAJ).

Undersøgelsen er en meta-analyse af 8 store observationsundersøgelser (observational studies), der vil undersøge om SSRI reducerer eller øger risikoen for selvmord hos mennesker med depression.

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Ketamine treatment for depression?

Experimental Antidepressant Use

According to a National Institute of Mental Health press release on 7 August 2006, a study of 17 patients led by Dr Carlos Zarate Jr. of the NIMH showed that ketamine significantly improved treatment-resistant major depression within two hours of injection. The improvement lasted up to one week after the single dose. The patients in the study were previously treatment resistant, having tried an average of six other treatments that failed. The importance of these findings was articulated by NIMH director Dr Thomas Insel: “This is the first report of any medication or other treatment that results in such a pronounced, rapid, prolonged response.” The researchers apparently attribute the effect to ketamine being an NMDA receptor antagonist.

The study appears in the Archives of General Psychiatry.

(About Ketamine, see: Wikipedia: Ketamine.) Læs resten

Deep Brain Stimulation Shows Promise in Treatment of Major Depression and OCD

Conference Report from The American Association of Neurological Surgeons annual meeting 2006 is showing promise results in treatment refactory OCD:

SAN FRANCISCO, April 24 — Deep brain stimulation significantly reduced symptoms of obsessive compulsive disorder (OCD) according to long-term results of a pilot study reported today.

Four of eight patients followed for 36 months after implantation of the stimulator had a reduction of at least 35% in OCD symptoms and two more patients reduced symptoms by 25% to 35%, said Ali Rezai, M.D., chairman of the Cleveland Clinic Center for Neurological Restoration, at the American Association of Neurological Surgeons meeting here.

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Cognitive Therapy Successful Against Depression

A new study published in the April Archives of General Psychiatry challenges the widely accepted idea that drugs are the only effective, initial treatment for major depression.