Tag-arkiv: Obsessive

OCD Video

It’s a Brain thing: OCD

Learn about obsessive/compulsive disorder. Some interesting data about the physical changes both psychotherapy and medications make on PET scans in folks with OCD.

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Vigtigt protein mangler hos OCD-ramte

brainForskere har fundet frem til at et protein sandsynligvis spiller en væsentlig rolle ved Obsessive Compulsive Disorder.

Det ser ud til, at der er en dysfunktion i det cortico-striato-thalamo-cortical kredsløb, der også har indflydelse på OCD. Proteinet SAPAP3, også kendt som DLGAP3, er et protein, der findes i striatum, hvor det er vigtigt for at signaler kan sendes over synapsekløften, altså at nerverne kan ’snakke’ sammen. Striatum er et område i hjernen, der håndtere planlægningen og udførelsen af bevægelser samt andre kognitive funktioner – et område i hjernen, der er en vigtig ‘beslutningstager’.

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Counting the OCD suffers

Hvor mange lider af OCD? Tja, det afhænger af hvilket diagnosesystem man benytter. Indtil 1970’erne antog man at det drejede sig om et beskedent antal personer. Så udførte man en række epidemiologiske undersøgelser bl.a. i USA, hvor man kom frem til at det nok var et sted mellem 2% til 3%, hvilket blev bekræftet af andre studier rundt om i verden. En australsk undersøgelse, der publiceres i det seneste nummer af American Journal of Psychitry, er kommet frem til at det ‘kun’ drejer sig om 0,6% af en population, hvis man følger DSM-IV kriterierne for at få diagnosen OCD. De tidligere undersøgelser blev udført efter DSM-III kriterierne for at få diagnosen OCD.
Det rejser spørgsmålet: hvornår har man OCD (og andre psykiatriske lidelser)? Er det når man har fået stillet diagnosen efter DSM-III, DSM-IV, DSM-IV TR eller ICD 9 eller 10 ? (ICD-10 er WHOs diagnosesystem og benyttes bl.a. i Danmark).
DSM-IV TR er en revideret version af DSM-IV og man kan selvfølgelig spørge om hvorfor de australske forskere ikke har anvendt denne? Forskerne har åbnet en interessant diskussion om diagnostik af OCD og man kan kun håbe at der opnås en konsensus i fagkredse om at stille den korrekte diagnose.
Der skal dog lige tilføjes at opfatte OCD (og sikkert andre psykiske lidelser) som konstant i en befolkning er misvisende, fordi årsagerne til OCD er mange, bl.a. ser man efter store influenzaepidemier (såkalte pandemier) en øget forekomst af OCD.

Counting the Counters
The rates of obsessive-compulsive disorder (OCD) in several epidemiological studies have been surprisingly high, up to 2.5% of the general population. Broad diagnostic criteria and lay interviewers may have led to overcounting. Many people have intrusive thoughts and ritualized behaviors, but generally these do not interfere with our lives. Crino et al. (p. 876) report an Australian survey of 10,641 adults that included only obsessions or compulsions causing marked distress, consuming substantial time, and interfering with functioning. By these standards, OCD was present in 0.6% of the population. OCD was often accompanied by other psychiatric disorders, but substance abuse was less common than in other surveys. Compared to earlier diagnostic systems, the current criteria were more likely to identify people who are disabled, receive medical services, and are unemployed. This suggests a more accurate identification of people with true illness.

Source: American Journal of Psychitry 162:A64, May 2005, In This Issue: Counting the Counters

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OCD caused by bacteria and viruses ?

Den engelske avis, The Guardian, har publiceret en artikel om at flere sygdomme end måske hidtil antaget dybest set er forårsaget af infektioner.

Obsessive compulsive disorder, schizophrenia and diabetes could be caused by bacteria and viruses, according to the American Academy of Microbiology. In a report, it says a huge number of conditions currently attributed to lifestyle and genetics, including psychiatric syndromes, could be down to microorganisms.

“A number of chronic human illnesses are triggered, either directly or indirectly, by microorganisms,” says Ronald Luftig of Louisiana State University Medical Centre, one of the authors of the report.

Source: The Guardian, Thursday April 28, 2005, Infected by mental illness

Double-Blind Treatment With Oral Morphine in Treatment-Resistant Obsessive-Compulsive Disorder

For people with obsessive-compulsive disorder (OCD) who have not been helped by standard drug treatments, a weekly dose of oral morphine may ease their symptoms, according to a small pilot study.

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Medtronic Receives Humanitarian Use Device Designation for Treatment of OCD

Den amerikanske virksomhed Medtronic vil snart søge godkendelse hos den amerikanske lægemiddelstyrelse Food and Drug Agency om godkendelse af deres produkt Activa til behandling af behandlingsresistent OCD. Activa benytter Deeb Brain Stimulation terapi og er reversibel modsat for eksempel neurokirurgi.

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Welcome to the Official P.A.N.D.A.S Web Page

PANDAS

PANDAS, is an abbreviation for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. The term is used to describe a subset of children who have Obsessive Compulsive Disorder (OCD) and/or tic disorders such as Tourette’s Syndrome, and in whom symptoms worsen following strep. infections such as "Strep throat" and Scarlet Fever…

The Official P.A.N.D.A.S Web Page 

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